Skin treatment update: Polynucleotide

In the world of cosmetic treatments, change is constant. Skin fillers, once considered the ultimate solution for plumping and firming the skin, are evolving into new-generation bio-stimulators—specifically, polynucleotides, which contain a unique ingredient derived from salmon sperm. Editor Trudi Brewer highlights this innovation, which emphasises enhancing the skin’s natural rejuvenation processes. Read on to learn more.

One doctor who champions safety first is Dr Joanna Romanoska of Clinic 42. Recently awarded Trainer of the Year by the NZ Society of Cosmetic Medicine, she is often our go-to for new skincare innovations. As far as Polynucleotides (PN) or Polydeoxyribonucleotide (PDRN) is concerned, this ingredient is derived from highly purified salmon DNA, which is 95 per cent similar to human DNA, making it effective at repairing skin at a cellular level. Here, she explains why we will be hearing more and more about polynucleotides, which are changing the face of cosmetic medicine.

Dr Joanna Romanowska

Editor Trudi Brewer shares what to expect from this treatment

Editor Trudi Brewer

As a self-proclaimed injectable pro, it's safe to say I know my way around the benefits of natural-looking appearance medicine. As a patient of Joanna Romanowska for decades, I know what to expect with her gentle bedside manner. Calm, ultra-gentle injectable style and breadth of knowledge in the latest age-erasing treatments. This one starts with numbing cream under my eyes and upper lip for about 30 minutes. Initially, I thought I could tough this out without the cream, but the injections had a bite, and I was grateful for the numbing. Injecting small amounts of the salmon sperm closely together, all under the eye area, into the crow's feet, and then along the top of the lip area, once underway, the treatment was fairly speedy. I was sporting needle marks when I left, and my skin felt tight, but this side effect subsided by the early evening. My under-eye area was slightly red for the next few days, but easily covered with mineral makeup. This stimulating treatment is a slow burn; there is no instant change, so you need to measure your expectations with results. For someone who is very impatient, that is tricky, but this treatment takes time to stimulate collagen production and show any firming changes. Two treatments in, I will report back in a few months with before-and-after photos.

Alongside other non-surgical treatments, such as dermal fillers and skin boosters, like Profhilo, Dr Joanna Romanowska now has polynucleotide treatments in her arsenal to boost skin rejuvenation. A master injector, she believes the cosmetic benefits of polynucleotides are both short- and long-term for skin rejuvenation, and that they will gain traction worldwide as a go-to skin booster. Here, Romanowska outlines the safety of this glow-giving bio-stimulator.

What are polynucleotide injections?

Polynucleotides are segments of DNA that have stimulatory and anti-inflammatory properties in tissues. When injected into the body, they stimulate repair and regeneration of the treated area. They are used for tendon repair, to accelerate surgical scar recovery, and to improve the texture of ageing skin.

Why is salmon sperm in the spotlight right now?

It is in the spotlight and for good reason. The injectable polynucleotides have been derived from salmon sperm DNA, which has been scientifically shown to have anti-ageing and regenerative properties, and are often referred to as a natural’ alternative’ to dermal fillers.

How do they work in the skin?

The mechanism is not completely understood, but Polynucleotides contain specific nucleotide sequences that match human cellular receptors, allowing them to integrate into repair mechanisms. Once injected, these molecules attract water molecules, creating a microenvironment that supports cellular activity while releasing growth factors that appear to promote healing and repair. However, the effects take two to three months for the results to become evident. 

What skin types and ages will benefit from polynucleotide injections?

Because there is no shape change from the injections (unlike with hyaluronic fillers), they can safely be used on all skin types. For either delaying the ageing process in the younger patient, where there will be a very modest, if any, visible change, or stimulating a repair process with more obvious effects in the older or sun-damaged patient’s skin. 

How do they differ from traditional fillers?

Because the results are from a bio-stimulatory process in the skin rather than a volumising effect in volume-depleted subcutaneous (beneath or under the layers of the skin) areas, they can be used in areas where shape change is undesirable. Unlike with most traditional fillers, the results take a couple of months after the last injection session to become fully evident. There is no instant gratification with this treatment.

What are the benefits, short and long term?

Initially, there may be some swelling following the procedure, which may smooth the skin. Still, the full effect of new collagen production, with tightening of the skin and possible improvement in dark circles under the eyes, takes longer to become evident. The results should last six to nine months, with individual variability.

How many treatments do you need, and how far apart are they?

We recommend repeating treatments monthly, with two to three treatments usually required, depending on the individual’s skin. 

What is the cost? 

Each treatment costs $900.

Disclaimer: REJURAN is a dermal tissue-reconstructive material derived from animals. REJURAN is an injectable gel intended for injection into the mid to deep dermis to promote tissue restoration and reconstruction and improve physical appearance. Administered by injecting the gel into the dermis using a thin-gauge needle. The polynucleotide hydrates cause volumetric increases in tissues, creating more favourable physiological conditions for the growth of skin cells. REJURAN treatment is not funded under the New Zealand Pharmaceutical Schedule. You will need to pay for this medicine. Normal doctor's visit fees apply. REJURAN treatment should be administered only by trained medical professionals. Speak to your doctor about your own situation and about the benefits/risks of this procedure in appearance medicine. For further information, the Data Sheet and Consumer Medicines Information can be accessed at www.medsafe.govt.nz or ask your doctor. If you have any side effects or concerns, speak to your doctor.